Vitality
The Vitality skill is used when a character is performing strenuous activity or hanging onto life by a thread. Many environmental effects require a Vitality roll to shrug off, such as extreme heat, cold, thin air, or no air. Many spells ask for the Grunt Save which involves Vitality and Endurance.
Difficulty
The DL for environmental effects is extremely varied. In general, it should be based on the extremeness of the climate. Your GM has the final call, as always, for determining DL for these.
A character that is suffering from environmental effects (heat, cold, etc.) takes a −2 to all rolls. Each hour a character is in a harsh environ, a new roll must be made. Failed attempts add penalties cumulatively.
Opposed Rolls
Vitality is sometimes used in conjunction with Endurance against a Spell Attack or Special Power.
Retries
Vitality attempts cannot be retried without spending a fate point.